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Nature Medicine

A small-molecule inverse agonist of PPARγ for advanced solid tumors: a phase 1 trial

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Nature Medicine, Published online: 28 February 2026; doi:10.1038/s41591-026-04263-3 Results from a phase 1 trial of a first-in-class small-molecule inverse agonist of PPARγ in solid tumors show an acceptable safety profile and preliminary tumor activity in urothelial carcinoma.

Nature Medicine, Published online: 28 February 2026;

doi:10.1038/s41591-026-04263-3

Results from a phase 1 trial of a first-in-class small-molecule inverse agonist of PPARγ in solid tumors show an acceptable safety profile and preliminary tumor activity in urothelial carcinoma.

— Source: Nature Medicine (https://www.nature.com/articles/s41591-026-04263-3)

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