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Nature Medicine

A cognitive layer architecture to support large-language model performance in psychotherapy interactions

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Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04278-w A real-world study showed that introducing a cognitive layer architecture to support specialized psychotherapeutic reasoning capabilities in general-purpose chatbots improved depression and anxiety symptoms compared to chatbots or therapists alone.

Nature Medicine, Published online: 12 March 2026;

doi:10.1038/s41591-026-04278-w

A real-world study showed that introducing a cognitive layer architecture to support specialized psychotherapeutic reasoning capabilities in general-purpose chatbots improved depression and anxiety symptoms compared to chatbots or therapists alone.

— Source: Nature Medicine (https://www.nature.com/articles/s41591-026-04278-w)

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