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Nature Biotechnology

Quantifying endosomal escape in vivo to guide lipid nanoparticle design

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Nature Biotechnology, Published online: 11 March 2026; doi:10.1038/s41587-026-03047-x A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery.

Nature Biotechnology, Published online: 11 March 2026;

doi:10.1038/s41587-026-03047-x

A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery.

— Source: Nature Biotechnology (https://www.nature.com/articles/s41587-026-03047-x)

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