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Nature Medicine

Shifting the goalposts in obesity drug development

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Nature Medicine, Published online: 23 June 2026; doi:10.1038/s41591-026-04462-y Obesity drug development must move beyond an emphasis on ever-greater weight loss to prioritize tolerability, sustainable benefits and medication persistence; two recent trials exemplify this shift, with more underway.

Nature Medicine, Published online: 23 June 2026;

doi:10.1038/s41591-026-04462-y

Obesity drug development must move beyond an emphasis on ever-greater weight loss to prioritize tolerability, sustainable benefits and medication persistence; two recent trials exemplify this shift, with more underway.

— Source: Nature Medicine (https://www.nature.com/articles/s41591-026-04462-y)

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