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Nature Medicine

Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial

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Nature Medicine, Published online: 17 February 2026; doi:10.1038/s41591-026-04222-y A pragmatic, cluster randomized trial in rural Guangdong, China, showed that 12-month implementation of a comprehensive antibiotic stewardship program involving physician training, point-of-care prompts, monthly peer review feedback and smartphone-based patient education substantially reduced antibiotic prescriptions for acute respiratory infections compared to control consultations.

Nature Medicine, Published online: 17 February 2026;

doi:10.1038/s41591-026-04222-y

A pragmatic, cluster randomized trial in rural Guangdong, China, showed that 12-month implementation of a comprehensive antibiotic stewardship program involving physician training, point-of-care prompts, monthly peer review feedback and smartphone-based patient education substantially reduced antibiotic prescriptions for acute respiratory infections compared to control consultations.

— Source: Nature Medicine (https://www.nature.com/articles/s41591-026-04222-y)

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