Breaking Breaking
Nature Medicine

Bispecific T cell engagers for treatment-refractory autoimmune connective tissue diseases

myndfocal
Nature Medicine, Published online: 19 February 2026; doi:10.1038/s41591-026-04238-4 In a case series of five patients with treatment-refractory antisynthetase syndrome and five patients with treatment-refractory systemic sclerosis, bispecific T cell engagers blinatumomab and teclistamab improved disease activity and were well tolerated.

Nature Medicine, Published online: 19 February 2026;

doi:10.1038/s41591-026-04238-4

In a case series of five patients with treatment-refractory antisynthetase syndrome and five patients with treatment-refractory systemic sclerosis, bispecific T cell engagers blinatumomab and teclistamab improved disease activity and were well tolerated.

— Source: Nature Medicine (https://www.nature.com/articles/s41591-026-04238-4)

Health
Read original on Nature Medicine →